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Volume 33 #2

Contents

  1. Computation of eye optics of the cetacean’s eye
  2. Neurophysiological mechanisms of two sequential orientations comparison in working memory
  3. Contribution of the marginal peripheral retina to color constancy: Evidence obtained due to contact lens with implanted occluder
  4. Contribution of the spectral and temporal mechanisms to analysis of complex sound signals
  5. Role of the donor of NO molecules in regulation of primary sensory neuron responses
  6. Identity documents forgery detection with mobile devices
  7. Transient processes of visual evoked potentials in the tasks of human-computer interfaces
  8. Algebraic reconstruction in case of limited GPU memory in the task of computed tomography
  9. New criteria for neural network encoder learning in the string segmentation problem

Role of the donor of NO molecules in regulation of primary sensory neuron responses

© 2019 V. B. Plakhova, V. A. Penniyaynen, I. V. Rogachevsky, A. D. Kalinina, S. A. Podzorovaa, B. V. Krylov

Pavlov Institute of Physiology of Russian Academy of Sciences, 199034 St. Petersburg, Makarova emb., 6, Russia

Received 27 Sep 2018

vThe effects of sodium nitroprusside (SNP), a donor of NO molecules, on primary sensory neurons were studied by patch- clamp and organotypic nerve tissue culture methods. SNP (10–2 M) has been found to decrease the voltage sensitivity of NaV1.8 channels which are responsible for nociceptive information coding. The data obtained in organotypic nerve tissue culture indicate that this agent applied at concentrations exceeding 10–4 M inhibits the growth of neurites. Our results demonstrate that antinociceptive effect of SNP, which is based on decreasing the voltage sensitivity of NaV1.8 channels is associated with negative inhibitory action on the development of embryonic nerve tissue in warm-blooded animals. It is suggested that the modulating effect of the NO-ergic system on the nociceptive system is unlikely to be exhibited at the primary sensory neuron level.

Key words: nociception, sensory neurons, patch-clamp method, organotypic nerve tissue culture method, NaV1.8 channels, sodium nitroprusside

DOI: 10.1134/S0235009219020069

Cite: Plakhova V. B., Penniyaynen V. A., Rogachevsky I. V., Kalinina A. D., Podzorovaa S. A., Krylov B. V. Rol donora molekul no v regulyatsii otvetov pervichnogo sensornogo neirona [Role of the donor of no molecules in regulation of primary sensory neuron responses]. Sensornye sistemy [Sensory systems]. 2019. V. 33(2). P. 135-141 (in Russian). doi: 10.1134/S0235009219020069

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