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Fundamental principles of odor perception for higher fatty aids V. Ì. Ganshina and E. P. Zinkevich

© 2018 V. M. Ganshin, E. P. Zinkevich

Institute of Ecology and Evolution A.N. Severtsov RAS, 119071 Moscow, Leninsky Prospect, 33, Russia

Received 10 Nov 2017

On the basis of model of competitive interaction of odorous substances with functional complexes (olfactory receptor – lipids of sensory membrane) lead theoretical estimations of sizes of olfactory thresholds for normal fatty acids with various length aliphatic chains. Results of calculations allow to draw a conclusion on existence of dependence of sizes of olfactory thresholds fatty acids from length of aliphatic circuits that allows to give an adequate substantiation to experimental data received of some authors. Character of the dependences received settlement by and in experiment, confirms a hypothesis about a role of competitive attitudes in primary processes in olfactory reception.

Key words: olfactory threshold, odorant-binding protein, olfactory mucus, sensory membrane, olfactory receptor protein, G-protein, cAMP-dependent cation channels, Ca2+-controlled chloride channels

DOI: 10.1134/S0235009218030071

Cite: Ganshin V. M., Zinkevich E. P. Fundamentalnye zakonomernosti obonyatelnogo vospriyatiya vysshikh zhirnykh kislot [Fundamental principles of odor perception for higher fatty aids v. ì. ganshina and e. p. zinkevich]. Sensornye sistemy [Sensory systems]. 2018. V. 32(3). P. 189–197 (in Russian). doi: 10.1134/S0235009218030071

References:

  • Bronstein A.A. Vkus i obonianie [Taste and smell]. M.; L. 1950. 307 p. [in Russian].
  • Ganshin V.M., Zinkevich E.P. Мekhanismi transduktsii oboniatelnikh signalov: vozmozhnaia rol sокrаtitelnogo apparata oboniatelnikh resnichek [The mechanisms of olfactory transduction of signals: the possible role of the contractile apparatus of the olfactory cilia] Sensornye systemy [Sensory Systems] 2017а. V. 31. № 1. P. 57–69 [in Russian].
  • Ganshin V.M., Zinkevich E.P. Prostranstvennoe i vremennoe integrirovanie v tsepy transduktsii oboniatelnikh signalov [Spatial and temporal integration in the chain transduction of olfactory signals]. Sensornye systemy [Sensory Systems]. 2017б. Т. 32. № 3. С. 237–246 [in Russian].
  • Duhovich F.S., Darhovskii M.B., Gorbatova E.N., Kurochkin V.K. Zavisimost. mezhdu коnstantoy dissotsiatsiy i vremenm zhizny коmpleksov fisiologichesky aktivnikh vevechestv s retseptoramy y fermentamy [The relationship between the dissociation constant and lifetime of the complexes of physiologically active substances with receptors and enzymes] [Chym.-farm. Zh.] Chemical.-farm. J. 2002. V. 36. № 5. P. 26–32 [in Russian].
  • Duhovich F.S., Darhovskii M.B., Gorbatova E.N., Kurochkin V.K. Molecularnoe uznavanie [Molecular recognition]. М. Medicine, 2004. P. 39–41 [in Russian].
  • Egorov A.M., Osipov A.D., Dzantiev B.B., Gavrilova E.M. Teorya i practika immunofermentnogo analiza. [Theory and practice of enzyme immunoassay]. М. “Visshaia shcola”. 1991. 288 p. [in Russian].
  • Zinkevich E.P., Moiseeva T.F., Starovoitov E.I., Sulimov K.T. Individualnie veschestva v zapakhovikh sledakh cheloveka [Individual substances in the olfactory traces of the human] Expert practice and new research methods. Moscow. VNIISE.1993. Issue 11. P. 6–13 [in Russian].
  • Commissarchic Y.Yu. Structura i khimichesky sostav kletochnikh membran. [Structure and chemical composition of cell membranes]. Commissarchic Y.Yu. Structure and functions of biological membranes. “The science”. M. 1975. P. 8 – 25 [in Russian].
  • Minor A.V. Strukturnay organizatsya perifericheskykh otdelov оbonyatelnogo аnalizatora i oboniatelnoy lukovitsy. [The structural organization of the peripheral parts of the olfactory analyzer and olfactory bulb]. Physiology of sensory systems. Part 2. 1972. P. 515–549 [in Russian].
  • Sulimov K.T. Biologicheskaya identifikatsia individa po oboniatelnim signalam. [Biological identification of the individual by olfactory signals]. The dissertation author’s abstract on competition of a scientific degree of the candidate of biological sciences. M. 1995. 24 p. [in Russian]
  • Sulimov K.T., Starovoytov V.I., Moiseyeva T.F., Poletaeva I.I., Zinkevich E.P. Oboniatelnoe razlichenie sobakami smesey trekh visshikh zhirnikh kislot po ikh kolichestvennomu sostvu [Olfactory distinction by dogs of three mixtures of higher fatty acids for their quantitative composition Sensornie systemy [Sensory Systems]. 1995. V. 9. № 2–3. P. 43–49 [in Russian].
  • Torchinsky Yu.M.. Sera v belkakh [Sulfur in proteins]. M.: Nauka, 1977. 302 p. [in Russian].
  • Beets M.G.J. Structure and odour. Molecular structure and organoleptic quality, S.C.I. Monograph № 1, Society of chemical industry. London. 1957. P. 54–90.
  • Bersuker I.B., Dimoglo A.S., Gorbachov M.Y., Greni A.I., Vysotskaya L.E., Mikhailova T.V. Study of the electronic and structural properties of the chemical compounds in garlic aroma. Food/Nahrung. 1989. V. 33. P. 405–411.
  • Devos M., Patte F., Rouault J., Laffort P., van Gemert L.J. Standardized Human Olfactory Thresholds. NY. Oxford University Press, 1990. 176 p.
  • Fazzalari F.A. Compilation of odor and taste threshold values data. American society for testing and materials. Philadelphia. PA. USA. 1978. 479 p.
  • Goeke A. Sulfur-containing odorants in fragrance chemistry. Sulfur Reports. 2002. V. 23. P 243–278.
  • Laffort P. Essai de standardisation des seuils olfactifs humains pour 192 corps purs. Arch. Sci. Physiol. 1963. V. 17. P. 75–105.
  • Liu A.H., Zhang X., Stolovitzky G.A., Califano A., Firestein S.J. Motif-based construction of a functional map for mammalian olfactory receptors. Genomics. 2003. V. 81. P. 443–456.
  • van Gemert L.J. Compilations of odour threshold values in air, water and other media. Oliemans, Punter and Partners BV. Zeist. The Netherlands. 2006. 378 p.
  • Walker J.C., Hall S.B., Walker D.B., Kendal-Reed M.S., Hood A.F., Niu X.F. Human odor detectability: new methodology used to determine threshold and variation. Chem. Senses. 2003. V. 28. P. 817–826.
  • Zarzo M. The sense of smell: molecular basis of odorant recognition. Biol. Rev. 2007. V. 82. P. 455–479.
  • Zarzo M. Effect of functional group and carbon chain length on the odor detection threshold of aliphatic compounds. Sensors (Basel). 2012. V. 12. № 4. P. 4105–4112.