• 1990 (Vol.4)
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Volume 38 #1

Contents

  1. Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research
  2. Changes in the visual areas of the cerebral cortex in children with left-sided anisometropic amblyopia according to structural MRI and resting-state fMRI
  3. In search of the molecular mechanisms of adaptation memory in rods: basic activity of phosphodiesterase
  4. Non-invasive recording of electroretinogram from both compound eyes in the cockroach Periplaneta americana L. in response to light stimuli
  5. Individual and typological features of motor memory in problems of control of ergacy systems in the absence of visual feedback
  6. Discrimination of rippled spectra with various ripple widths in listeners with normal and impaired hearing

Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research

© 2024 A. V. Gorskaya, D. S. Vasilev

Sechenov Institute of Evolutionary Physiology and Biochemistry of the RAS 194223, Saint Petersburg, Thorez, 44, Russia

Received 24 Nov 2023

Olfactory impairment (decreased acuity, impaired adequate identification of odorants) reduces the quality of life of patients and can be a symptom of a wide range of pathologies of the organism, in particular neurodegenerative processes in the brain. Quantitative measurement of olfactory acuity is necessary for diagnostics of olfactory dysfunctions, monitoring the dynamics of olfaction after pharmacological or surgical treatment. The searching for optimal methods of analyzing olfactory thresholds on animal models of human diseases accompanied by anosmia and comparing them with those in humans seems to be especially urgent problem at the moment. This is necessary for the selection of a valid animal model for the evaluation of new drugs and development the therapy for a wide range of pathologies. The review analyzes publications devoted to the study of diseases accompanied by anosmia or hyposmia, their zootropic models, and methods of olfactory function assessment. Models for COVID19, Alzheimer’s disease, Parkinson’s disease, diabetes types (1 and 2 type), Kalman syndrome, and BardetBiedl syndrome, for which olfactory dysfunction and/or defects of olfactory system are present, were analyzed. The review notes the paucity of data on the measurement of olfactory thresholds in model animals.

Key words: anosmia, Alzheimer’s disease, Parkinson’s disease, diabetes, COVID-19

DOI: 10.31857/S0235009224010017

Cite: Gorskaya A. V., Vasilev D. S. Problemy diagnostiki disfunktsii obonyatelnogo analizatora laboratornykh zhivotnykh na osnove povedencheskikh i elektrofiziologicheskikh metodov issledovaniya [Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research ]. Sensornye sistemy [Sensory systems]. 2024. V. 38(1). P. 3–29 (in Russian). doi: 10.31857/S0235009224010017

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