• 1990 (Том 4)
  • 1989 (Том 3)
  • 1988 (Том 2)
  • 1987 (Том 1)

Том 38 №1

Содержание

  1. ПРОБЛЕМЫ ДИАГНОСТИКИ ДИСФУНКЦИЙ ОБОНЯТЕЛЬНОГО АНАЛИЗАТОРА ЛАБОРАТОРНЫХ ЖИВОТНЫХ НА ОСНОВЕ ПОВЕДЕНЧЕСКИХ И ЭЛЕКТРОФИЗИОЛОГИЧЕСКИХ МЕТОДОВ ИССЛЕДОВАНИЯ
  2. ИЗМЕНЕНИЯ В ЗРИТЕЛЬНЫХ ЗОНАХ КОРЫ ГОЛОВНОГО МОЗГА У ДЕТЕЙ ПРИ ЛЕВОСТОРОННЕЙ АНИЗОМЕТРОПИЧЕСКОЙ АМБЛИОПИИ ПО ДАННЫМ СТРУКТУРНОЙ МРТ И ФУНКЦИОНАЛЬНОЙ МРТ ПОКОЯ
  3. В ПОИСКАХ МОЛЕКУЛЯРНЫХ МЕХАНИЗМОВ АДАПТАЦИОННОЙ ПАМЯТИ ПАЛОЧЕК: БАЗОВАЯ АКТИВНОСТЬ ФОСФОДИЭСТЕРАЗЫ
  4. НЕИНВАЗИВНАЯ РЕГИСТРАЦИЯ ЭЛЕКТРОРЕТИНОГРАММЫ ОТ ОБОИХ СЛОЖНЫХ ГЛАЗ У ТАРАКАНА PERIPLANETA AMERICANA L. В ОТВЕТ НА СВЕТОВЫЕ СТИМУЛЫ
  5. СЕНСОРНЫЕ ОСОБЕННОСТИ ОПЕРАТОРОВ В ЗАДАЧАХ УПРАВЛЕНИЯ ЭРГАТИЧЕСКИМИ СИСТЕМАМИ ПРИ ОТСУТСТВИИ ЗРИТЕЛЬНОЙ ОБРАТНОЙ СВЯЗИ
  6. РАЗЛИЧЕНИЕ ГРЕБЕНЧАТЫХ СПЕКТРОВ С РАЗНОЙ ШИРИНОЙ ГРЕБНЕЙ В НОРМЕ И ПРИ ТУГОУХОСТИ

ПРОБЛЕМЫ ДИАГНОСТИКИ ДИСФУНКЦИЙ ОБОНЯТЕЛЬНОГО АНАЛИЗАТОРА ЛАБОРАТОРНЫХ ЖИВОТНЫХ НА ОСНОВЕ ПОВЕДЕНЧЕСКИХ И ЭЛЕКТРОФИЗИОЛОГИЧЕСКИХ МЕТОДОВ ИССЛЕДОВАНИЯ

© 2024 г. А. В. Горская, Д. С. Васильев

Институт эволюционной физиологии и биохимии имени И. М. Сеченова РАН 194223, Санкт-Петербург, ул. Тореза 44, Россия
dvasilyev@bk.ru

Поступила в редакцию 24.11.2023 г.

Нарушение обоняния (снижение остроты, нарушение адекватной идентификации запахов) снижает качество жизни пациентов и может быть симптомом широкого спектра патологий организма, в частности нейродегенеративных процессов в отделах головного мозга. Количественное измерение остроты обоняния необходимо для диагностики обонятельных дисфункций, отслеживания динамики обоняния после лечения или хирургического вмешательства. Особенно актуальной в настоящий момент видится проблема поиска оптимальных методов анализа обонятельных порогов на животных моделях заболеваний человека, сопровождающихся аносмией, и сопоставление их с таковыми. Это необходимо для подбора валидной животной модели с целью разработки новых лекарственных средств и методов терапии широкого спектра патологий. В обзоре проведен анализ публикаций, посвященных исследованию заболеваний, сопровождающихся аносмией или гипосмией, их животным моделям, методам оценки обонятельной функции. Разобраны модели для коронавирусной инфекции COVID-19, болезней Альцгеймера, Паркинсона, диабета 1 и 2 типов, синдрома Кальмана и Синдрома Барде–Бидля, для которых отмечены нарушения обонятельной функции и/или дефекты отделов обонятельной системы. В обзоре отмечается недостаточность данных об измерении обонятельных порогов у модельных животных.

Ключевые слова: саносмия, болезнь Альцгеймера, болезнь Паркинсона, диабет, COVID-19

DOI: 10.31857/S0235009224010017

Цитирование для раздела "Список литературы": Горская А. В., Васильев Д. С. Проблемы диагностики дисфункций обонятельного анализатора лабораторных животных на основе поведенческих и электрофизиологических методов исследования. Сенсорные системы. 2024. Т. 38. № 1. С. 3–29. doi: 10.31857/S0235009224010017
Цитирование для раздела "References": Gorskaya A. V., Vasilev D. S. Problemy diagnostiki disfunktsii obonyatelnogo analizatora laboratornykh zhivotnykh na osnove povedencheskikh i elektrofiziologicheskikh metodov issledovaniya [Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research ]. Sensornye sistemy [Sensory systems]. 2024. V. 38(1). P. 3–29 (in Russian). doi: 10.31857/S0235009224010017

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