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Probable role of p38 MAP-kinase in reception of infrared irradiation

© 2017 V. A. Penniyaynen, I. L. Yachnev, A. V. Kipenko, E. V. Lopatina, B. V. Krylov

Pavlov Institute of Physiology, RAS, 199034 Saint-Petersburg, Makarova emb., 6.
Almazov Federal Heart, Blood and Endocrinology Centre, 197341, Saint-Petersburg, Akkuratovast., 2.
Pavlov First Saint-Petersburg State Medical University, 197022, Saint-Petersburg, L’va Tolstogo str. 6/8.

Received 17 May 2016

Low-power (nonthermal) infrared (IR) irradiation activates transducer function of Na+, K+-ATPase that might be realized as basic molecular mechanism of reception for the stimuli of this modality. Investigation of neurite growth of sensory neurons of 10–12-days chicken embryos was done using organotypic tissue culture method. Low-power IR irradiation (energy density was equal to 2 ⋅ 10–10 J/cm2) inhibited the neurite growth. Participation of p38 MAPK in regulation of the transducer-coupled mechanism of intracellular signalization triggered by IR irradiation was elucidated using SB239063 inhibitor of p38 MAPK. Combined action of IR irradiation and SB239063 (1 mkM) eliminated inhibiting effect of IR irradiation on neurite growth. The data obtained allow to conclude that p38 MAPK participates in intracellular cascade processes in sensory neuron that are transducer-coupled triggered by low-power IR irradiation generated by СО2-laser.

Key words: sensory neuron, organotypic tissue culture, p38 MAPK, Na+, K+-АТPase, infrared irradiation

Cite: Penniyaynen V. A., Yachnev I. L., Kipenko A. V., Lopatina E. V., Krylov B. V. Rol r38 map-kinazy v retseptsii infrakrasnogo izlucheniya [Probable role of p38 map-kinase in reception of infrared irradiation]. Sensornye sistemy [Sensory systems]. 2017. V. 31(1). P. 11-15 (in Russian).

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