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Polysomnographic study of central sleep apnea in cats

© 2019 A. V. Limanskaya, I. I. Busygina, V. D. Lavrova, I. N. Pigarev

Institute for Information Transmission Problems (Kharkevich Institute) RAS, Moscow, Russia
Lomonosov Moscow State University, faculty of Biology, Moscow, Russia
Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia

Received 01 Oct 2018

Central sleep apnea syndrome is a reduction or a cessation of breathing during sleep induced by the command of breathing center (in brain stem) to the muscles. The issue whether Central Sleep Apnea is a pathological event that should be suppressed or it is an adaptive reaction of an organism is still actual. In the polysomnographic studies included EEG, ECG, Eye movements, air flow, stomach and duodenum myoelectric activity, temperature of brain and body in normal cats we often observed episodes of Central Sleep Apnea. The absence of breathing (for 9-13 seconds) generally performs in REM- sleep and in the transition states (from Slow-wave to REM sleep). All episodes of apnea were followed by stereotypic complex of reactions of all parameters recorded in our study. In the context of investigated visceral theory of sleep this complex of events followed the Central Apnea most likely is coordinated physiological adaptive function important for the recovering of organism.

Key words: sleep, visceral theory of sleep, polysomnography, sleep-related breathing disorders, central sleep apnea

DOI: 10.1134/S0235009219010098

Cite: Limanskaya A. V., Busygina I. I., Lavrova V. D., Pigarev I. N. Polisomnograficheskoe issledovanie tsentralnogo apnoe sna u koshek [Polysomnographic study of central sleep apnea in cats]. Sensornye sistemy [Sensory systems]. 2019. V. 33(1). P. 77-83 (in Russian). doi: 10.1134/S0235009219010098

References:

  • Lavrova V.D., Busigina I.I., Pigarev I.N. Otrazjenie raboti serdca v electroencephalogramme coschek v periodi medlennogo sna.[Heartbeat-evoked responses on EEG in slow wave sleep in cats]. Sensornye sistemy [Sensory Systems]. 2019. V. 33. N. 1. P. (in Russian).
  • Pigarev IN. Visceral’naya teoria sna. [The visceral theory of sleep]. Zhurnal Vysshii Nervnoi Deiatelnosti Im I.P. Pavlova. [I.P. Pavlov Journal of Higher Nervous Activity] 2013; V. 63. № 1. P. 86 –104 (in Russian).
  • Davis E.M., O’Donnell C.P. Rodent models of sleep apnea. Respiratory Physiology & Neurobiology. 2013. V. 4. № 5. P. 403–405.
  • Durand E., Dauger S., Pattyn A., Gaultier C., Goridis C., Gallego J. Sleep- disordered breathing in newborn mice heterozygous for the transcription factor Phox2b. American Journal of Respiratory and Critical Care Medicine. 2005. V. 172. P. 238–243.
  • Gay P.C. Complex sleep apnea: it really is a disease. J. Clin. Sleep Med. 2008. V. 15. № 5. P. 403–405.
  • Javaheri Sh., Dempsey J.A. Central sleep apnea. Comprehensive Physiology. 2013. V. 3. № 1. P. 141–163.
  • Javaheri Sh., Brown L.K., Khayat R.M. CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppresse. Journal of Clinical Sleep Medicine 2018. V. 14. № 6. P. 915–921.
  • Joseph V., Pequignot J.M., Van Reeth O. Neurochemical perspectives on the control of breathing during sleep. Respiratory Physiology & Neurobiology. 2002. V. 130. P. 253–263.
  • Koo B.B., Strohl K.P., Gillombardo C.B., Jacono. F.J. Ventilatory Patterning in a mouse model of stroke. Respiratory Physiology and Neurobiology. 2010. V. 172. №3. P. 129–135.
  • Malhotra A., Bertisch S., Wellman A. Complex sleep apnea: it isn’t really a disease. Journal of Clinical Sleep Medicine. 2008. V. 4. № 5. P. 406–408.
  • McGinty D.J., London M.S., Baker T.L., Stevenson M., Hoppenbrouwers T., Harper R.M., Sterman M.B., Hodgman J. Sleep apnea in normal kittens. Sleep. 1979. V. 1. № 4. P. 393–412.
  • Nakamura A., Fukuda Y., Kuwaki T. Sleep apnea and effect of chemostimulation on breathing instability in mice. Journal of Applied Physiology. 2003. V. 94. № 2. P. 525–532.
  • Naughton M.T. PRO: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppresse. Journal of Clinical Sleep Medicine. 2018. V. 14. № 6. P. 915–921.
  • Noda H., Freeman R.B., Gies B., Creutzfeldt O.D. Neural responses in the visual cortex of awake cats to stationary and moving targets. Experimental brain research. 1971. V. 12. P. 389–405.
  • Pigarev I.N., Rodionova E.I. Two visual areas located in the middle suprasylvian gyrus (cytoarchitectonic field 7) of the cat’s cortex Neuroscience. 1998. V. 85. № 3. P. 717–732.
  • Pigarev I.N., Saalmann Y.B., Vidyasagar T.R. A minimally invasive and reversible system for chronic recordings from multiple brain sites in macaque monkeys. J. Neurosci. Methods. 2009. V. 181. № 2. P. 151–158.
  • Sato T., Saito H., Seto K., Takatsuji H. Sleep apneas and cardiac arrhythmias in freely moving rats. American Journal of Physiology 1990. V. 259. P. R282–R287.
  • Stettner G.M., Huppke P., Brendel C., Richter D.W., Gartner J., Dutschmann M. Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice. Journal of Physiology. 2007. V. 579. P. 863–876.
  • Zimmermann M. Ethical principles for the maintenance and use of animals in neuroscience research. Neuroscience Lett. 1987. V. 73. № 1. P. 1.