• 2026 (Vol.40)
  • 1990 (Vol.4)
  • 1989 (Vol.3)
  • 1988 (Vol.2)
  • 1987 (Vol.1)

Volume 40 #1

Contents

  1. Neuronal Activity in the Temporal Cortex of the Unanesthetized Cat Synchronized with Respiration
  2. Behavioral Responses of the European Corn Borer to Ultrasonic Signals in Laboratory and Field Conditions
  3. Temporal Thresholds of Moving Sound Source Localization in Patients with Chronic Sensoryneural Hearing Loss and Central Auditory Processing Disorders
  4. Apperception Factors in Speech Signal Detection under Background of Spatially Distributed Multi-Speaker Noise
  5. The Effect of Glycine on Olfactory Sensitivity in Wistar Rats Mediated by an Excitatory Glycine Receptor
  6. Two-Channel Mechanism for Encoding Orientations in the Visual System

The Effect of Glycine on Olfactory Sensitivity in Wistar Rats Mediated by an Excitatory Glycine Receptor

© 2026 A.A. Zuykova, E.V. Bigdai, A.V. Pozdnyakov

Federal State Educational Institution of Higher Education “Saint-Petersburg State Pediatric Medical University” of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russian Federation

Received 10 Jan 2025

The excitatory glycine receptor (eGlyR) performs a neuroprotective function in central nervous system neurons. eGlyR is localized in the apical regions of olfactory sensory neurons (OSNs). Its main distinguishing feature is selective activation by glycine molecules, as well as its low permeability to calcium ions. However, the functional role of this receptor in olfactory receptor cells has not been sufficiently studied. Therefore, the aim of this study was to investigate whether glycine affects the olfactory sensitivity of OSNs. To achieve this goal, in vivo calcium fluorescence microscopy was used to record fluorescence changes in response to stimulation in the presence and absence of glycine. The obtained data allow us to assert that glycine affects the olfactory sensitivity of OSNs. Moreover, the responses of the receptor cells varied differently: in some, they were enhanced, while in others, they were weakened, up to complete disappearance. It is likely that such responses are due to the different sensitivities of olfactory sensory neurons to odors. Thus, glycine, via activation of the excitatory glycine receptor, can influence the olfactory sensitivity of sensory neurons.

Key words: excitatory glycine receptor, GluN3A subunit, olfactory sensory neurons, glycine

DOI: 10.7868/S3034593626010059

Cite: Zuykova A. A., Bigdai E. V., Pozdnyakov A. V. O vliyanii glitsina na obonyatelnuyu chuvstvitelnost krys linii vistar, oposredovannom vozbuzhdayushchim glitsinovym retseptorom [The effect of glycine on olfactory sensitivity in wistar rats mediated by an excitatory glycine receptor]. Sensornye sistemy [Sensory systems]. 2026. V. 40(1). P. 59–71 (in Russian). doi: 10.7868/S3034593626010059

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