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Effect of auditory LTP-like stimulation on the processing of sounds

© 2021 A. B. Rebreikina, D. F. Kleeva, G. A. Soghoyan, O. V. Sysoeva

Sirius University of Science and Technology 354340 Sochi, Adler district, Olympic Ave., 1, Russia
Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences 117485 Moscow, Butlerova str., 5A, Russia
University Higher school of Economics (HSE) 101000 Moscow, Myasnitskaya str., 20, Russia

Received 01 Dec 2020

Long-term potentiation is a persistent increase in synaptic strength following high-frequency electrical stimulation, a phenomenon initially studied in animals. Recent studies suggested that repeated sensory stimulation can elicit the effects similar to what is observed for electrical stimulation. Such LTP-like stimulation was used in few human studies, suggesting that it might result in an increase in differentiation of stimulated signals, as also reflected in an increase in the components of event-related potential (ERPs) such as N1 and MMN. Here we extend this line of research and examine long-term as well as short-term ERPs changes of LTP-like auditory stimulation (26 Hz) in adults. We used an odd-ball paradigm with standard (1000 Hz, 80%) and deviant signals (1020 Hz and 980 Hz, 10% each). This block was repeated 3 times, before LTP-like stimulation (targeted on 1020 Hz), immediately after the stimulation and 7–34 days after stimulation. Participants watched the silent movie. Unlike previous studies our main effect was related to the stimuli that was not used for the stimulation: N1 amplitude was decreased for the 1000 and 980 Hz stimuli. These changes refer to plastic rearrangements in the auditory cortex, which might be related to lateral inhibition. Observed effects had short-term patterns and did not preserve on the second visit after 7–34 days. However, N1 amplitude for 1020 Hz tone was increased on the second visit indicating some delayed potentiation effect for the stimulated auditory representation. Changes in MMN were not observed. Current results bridge work on the cellular level and the systemic level of the brain and provide a valid instrument for non-invasive examination of plasticity of auditory representation with potential implementation in pathophysiological conditions.

Key words: auditory evoked potentials (ERP), long-term potentiation (LTP), LTP-like stimulation, lateral inhibition, N1 component, mismatch negativity (MMN)

DOI: 10.31857/S0235009221020074

Cite: Rebreikina A. B., Kleeva D. F., Soghoyan G. A., Sysoeva O. V. Vliyanie slukhovoi ltp-podobnoi stimulyatsii na obrabotku zvukovykh stimulov [Effect of auditory ltp-like stimulation on the processing of sounds]. Sensornye sistemy [Sensory systems]. 2021. V. 35(2). P. 144–152 (in Russian). doi: 10.31857/S0235009221020074


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