Volume 33 #3

Contents

1. The algorithm for simulation of dichromatic vision and its application for detecting color vision deficiencies
2. Discrimination of frequency-amplitude patterns of rippled-spectrum signals with spectraland temporal-processing mechanisms of frequency analysis
3. Involvement of protein kinase C in receptor-mediated signaling processes
4. Spectral model of a single-channel X-ray measuring instruments with polychromatic radiation
5. Safe speed control of unmanned ground vehicle under ego-position uncertainty
6. Recognition of projectively transformed planar figures. XIII. New methods for projectively-invariant description of ovals, using a T-polar curve

Comenic acid is a specific agonist of opioid-like receptors found in the sensory neuron membrane. These receptors are coupled to NaV1.8 channels responsible for nociceptive information coding. Patch-clamp data show that at the membrane level, the ligand-receptor binding of comenic acid is manifested in a decrease in the effective charge transfer of NaV1.8 channels activation gating device. The use of a specific protein kinase C inhibitor (Tamoxifen) did not affect this receptor-activated mechanism. A completely different result is obtained at the tissue level: Tamoxifen totally blocks the signal triggered by comenic acid and directed radially to the nerve cell genome. Elimination of the neurite- stimulating effect of comenic acid by Tamoxifen demonstrates that protein kinase C participates in intracellular cascade processes under study as a sequential unit.

Key words: comenic acid, nociception, sensory neurons, patch-clamp method, organotypic nerve tissue culture method, NaV1.8 channels, protein kinase C

DOI: 10.1134/S0235009219030089

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