• 1990 (Vol.4)
  • 1989 (Vol.3)
  • 1988 (Vol.2)
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Volume 39 #3

Contents

  1. FREE AND BOUND FRACTION OF cGMP IN THE OUTER SEGMENT OF VERTEBRATE PHOTORECEPTORS
  2. DISEASE DETECTION BY VOLATILE ORGANIC COMPOUND ANALYSIS: I. DETECTION DOGS
  3. DISEASE DETECTION BY VOLATILE ORGANIC COMPOUND ANALYSIS: II. DIRECT SAMPLE INJECTION MASS SPECTROMETRY
  4. RESPONSE OF CELLS IN THE TEMPORAL CORTEX OF A NON-NARCOTISED CAT TO HUMAN SNORING SOUNDS
  5. FEATURES OF THE INFLUENCE OF NOISE BACKGROUND ONTHE CHOICE OF VISUAL STIMULI BY CHILDREN OF EARLY PRESCHOOL AGE WITH DIFFERENT LEVELS OF ANXIETY
  6. VIRTUAL SELECTIVE OCCLUSION BASED ON POLARIZATION 3D TECHNOLOGY IN FUNCTIONAL TREATMENT OF BINOCULAR VISION DISORDERS

DISEASE DETECTION BY VOLATILE ORGANIC COMPOUND ANALYSIS: II. DIRECT SAMPLE INJECTION MASS SPECTROMETRY

© 2025 S. M. Nikiforov, A. V. Pento, O. O. Kiryukhina, E. I. Rodionova

Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991, Vavilova St., 38, Moscow, Russia
Kharkevich Institute for information transmission problems, Russian Academy of Sciences, 127051, Bolshoy Karetny per., 19, build.1, Moscow, Russia

Received 14 Apr 2025

The results of the application of mass spectrometry with direct sample injection in the diagnosis of diseases in humans and laboratory animals are presented. Various methods for obtaining mass spectra of volatile organic compounds (VOCs) are considered, allowing VOCs analysis without using sample concentration and chromatographic separation. This approach, reminiscent of the work of trained sniffing dogs, ensures minimal sample analysis time and high sensitivity, which is extremely important for mass analysis. The authors’ own results on the development of a new method of VOC ionization for the analysis of biological samples are also presented.

Key words: mass spectrometry, volatile organic compounds, diagnosis of diseases

DOI: 10.7868/S3034593625030036

Cite: Nikiforov S. M., Pento A. V., Kiryukhina O. O., Rodionova E. I. Obnaruzhenie zabolevanii po analizu letuchikh organicheskikh soedinenii: ii. mass-spektrometriya s pryamym vvodom proby [Disease detection by volatile organic compound analysis: ii. direct sample injection mass spectrometry]. Sensornye sistemy [Sensory systems]. 2025. V. 39(3). P. 25–37 (in Russian). doi: 10.7868/S3034593625030036

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