• 1990 (Том 4)
  • 1989 (Том 3)
  • 1988 (Том 2)
  • 1987 (Том 1)

Том 36 №1

Содержание

  1. ОЦЕНКА ОСТРОТЫ ЗРЕНИЯ. 2. ТЕОРЕТИЧЕСКИЕ И КЛИНИЧЕСКИЕ ТРЕБОВАНИЯ К ОПТОТИПАМ И ДИЗАЙНУ ТАБЛИЦ
  2. ОЦЕНКА ПЕРИФЕРИЧЕСКОЙ ОСТРОТЫ ЗРЕНИЯ В РАЗЛИЧНЫХ УСЛОВИЯХ ТЕСТИРОВАНИЯ
  3. ЭКСПРЕССИЯ И ФУНКЦИОНАЛЬНАЯ РОЛЬ СИГНАЛЬНЫХ БЕЛКОВ ОБОНЯТЕЛЬНОЙ, ВКУСОВОЙ И ФОТОТРАНСДУКЦИИ В БЕТА-КЛЕТКАХ ОСТРОВКОВ ЛАНГЕРГАНСА
  4. РАСПОЗНАВАНИЕ ПРОЕКТИВНО ПРЕОБРАЗОВАННЫХ ПЛОСКИХ ФИГУР. XVI. ОКТЕТ ПРОЕКТИВНО СТАБИЛЬНЫХ ВЕРШИН ОВАЛА И НОВЫЕ МЕТОДЫ ЭТАЛОННОГО ЕГО ОПИСАНИЯ, ИСПОЛЬЗУЮЩИЕ ОКТЕТ
  5. УЧЕТ ГЕТЕРОСКЕДАСТИЧНОСТИ В ИЗМЕРЯЕМЫХ ТОМОГРАФИЧЕСКИХ ПРОЕКЦИЯХ ПРИ РЕАЛИЗАЦИИ АЛГЕБРАИЧЕСКОГО ПОДХОДА В ТОМОГРАФИЧЕСКОЙ РЕКОНСТРУКЦИИ

ЭКСПРЕССИЯ И ФУНКЦИОНАЛЬНАЯ РОЛЬ СИГНАЛЬНЫХ БЕЛКОВ ОБОНЯТЕЛЬНОЙ, ВКУСОВОЙ И ФОТОТРАНСДУКЦИИ В БЕТА-КЛЕТКАХ ОСТРОВКОВ ЛАНГЕРГАНСА

© 2022 г. Ю. А. Ковалицкая, Н. П. Коваленко, М. Ф. Быстрова

Институт биофизики клетки Российской академии наук, обособленное подразделение Федерального государственного бюджетного учреждения науки “Федеральный исследовательский центр “Пущинский научный центр биологических исследований РАН” 142290 г. Пущино, ул. Институтская, д. 3, Россия
marinabystrova@rambler.ru

Поступила в редакцию 13.09.2021 г.

Вкусовая, обонятельная и зрительная сенсорные системы обеспечивают рецепцию и распознавание физических и химических стимулов, возникающих в окружающей среде. Экспрессия сигнальных белков, вовлеченных во вкусовую, обонятельную и фототрансдукцию, обнаружена в бета-клетках островков Лангерганса поджелудочной железы млекопитающих, продуцирующих и секретирующих инсулин. Будучи впервые идентифицированными в обонятельных нейронах, вкусовых клетках, палочках и колбочках сетчатки, компоненты каскадов сенсорной трансдукции выполняют специфические функции в соответствующих сенсорных клетках. Роль этих молекул в физиологии бета-клеток до сих пор остается дискуссионной, а их экспрессия в отличие от экспрессии в специализированных сенсорных клетках носит не специфический, а эктопический характер. В настоящее время появились данные, показывающие, что сигнальные белки, вовлеченные в сенсорную трансдукцию, в бета- клетках могут участвовать в регуляции глюкозозависимой секреции инсулина. Обзор посвящен обобщению информации об экспрессии и функциональной активности элементов сенсорной трансдукции в бета-клетках млекопитающих, а также в модельных клеточных линиях инсулином мышей, крыс и хомяков, которые сохранили способность к синтезу и секреции инсулина.

Ключевые слова: бета-клетки, островки Лангерганса, секреция инсулина, эктопическая экспрессия, обонятельная трансдукция, вкусовая трансдукция, фототрансдукция

DOI: 10.31857/S0235009222010048

Цитирование для раздела "Список литературы": Ковалицкая Ю. А., Коваленко Н. П., Быстрова М. Ф. Экспрессия и функциональная роль сигнальных белков обонятельной, вкусовой и фототрансдукции в бета-клетках островков лангерганса. Сенсорные системы. 2022. Т. 36. № 1. С. 44–60. doi: 10.31857/S0235009222010048
Цитирование для раздела "References": Yu. A. Kovalitskaya, Kovalenko N. P., Bystrova M. F. Ekspressiya i funktsionalnaya rol signalnykh belkov obonyatelnoi, vkusovoi i fototransduktsii v beta-kletkakh ostrovkov langergansa [The expression and function of components of signaling cascades of taste, olfactory, and phototransduction in mammalian pancreas beta-cells]. Sensornye sistemy [Sensory systems]. 2022. V. 36(1). P. 44–60 (in Russian). doi: 10.31857/S0235009222010048

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