• 1990 (Том 4)
  • 1989 (Том 3)
  • 1988 (Том 2)
  • 1987 (Том 1)

Том 39 №3

Содержание

  1. СВОБОДНАЯ И СВЯЗАННАЯ ФРАКЦИЯ сGMP В НАРУЖНОМ СЕГМЕНТЕ ФОТОРЕЦЕПТОРОВ ПОЗВОНОЧНЫХ
  2. ОБНАРУЖЕНИЕ ЗАБОЛЕВАНИЙ ПО АНАЛИЗУ ЛЕТУЧИХ ОРГАНИЧЕСКИХ СОЕДИНЕНИЙ: I. СОБАКИ-ДЕТЕКТОРЫ
  3. ОБНАРУЖЕНИЕ ЗАБОЛЕВАНИЙ ПО АНАЛИЗУ ЛЕТУЧИХ ОРГАНИЧЕСКИХ СОЕДИНЕНИЙ: II. МАСС-СПЕКТРОМЕТРИЯ С ПРЯМЫМ ВВОДОМ ПРОБЫ
  4. РЕАКЦИЯ КЛЕТОК ВИСОЧНОЙ КОРЫ НЕНАРКОТИЗИРОВАННОЙ КОШКИ НА ЗВУКИ ЧЕЛОВЕЧЕСКОГО ХРАПА
  5. ОСОБЕННОСТИ ВЛИЯНИЯ ШУМОВОЙ НАГРУЗКИ НА ВЫБОР ЗРИТЕЛЬНЫХ СТИМУЛОВ У ДЕТЕЙ РАННЕГО ДОШКОЛЬНОГО ВОЗРАСТА С РАЗНЫМ УРОВНЕМ ТРЕВОЖНОСТИ
  6. ПРИМЕНЕНИЕ ВИРТУАЛЬНОЙ СЕЛЕКТИВНОЙ ОККЛЮЗИИ НА БАЗЕ ПОЛЯРИЗАЦИОННОЙ 3D-ТЕХНОЛОГИИ В ФУНКЦИОНАЛЬНОМ ЛЕЧЕНИИ РАССТРОЙСТВ БИНОКУЛЯРНОГО ЗРЕНИЯ

СВОБОДНАЯ И СВЯЗАННАЯ ФРАКЦИЯ сGMP В НАРУЖНОМ СЕГМЕНТЕ ФОТОРЕЦЕПТОРОВ ПОЗВОНОЧНЫХ

© 2025 г. М. Л. Фирсов

Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН, 194223, Санкт-Петербург, пр-т Тореза, д. 44, Россия
Michael.Firsov@gmail.com

Поступила в редакцию 01.11.2024 г.

Каскад фототрансдукции в фоторецепторах сетчатки позвоночных использует в качестве вторичного мессенджера циклический гуанозинмонофосфат (cGMP). Уровень cGMP управляет проводимостью каналов плазматической мембраны клетки, поэтому скорость, с которой меняется уровень cGMP, является критической для быстродействия фоторецептора. Существует кажущееся противоречие между высокой общей концентрацией cGMP в наружных сегментах и экспериментально измеренной высокой скоростью обмена cGMP. Противоречие может быть разрешено, если предположить, что большая часть cGMP находится в связанном состоянии, а динамическая фракция составляет незначительную долю от общего cGMP, но именно она изменяется под действием света и управляет проводимостью каналов. В настоящем обзоре мы разбираем доказательства разделения общего пула cGMP на связанную и свободную фракцию, вероятные сайты связывания cGMP и возможное функциональное значение существования двух фракций.

Ключевые слова: cGMP, PDE6, фоторецептор, сетчатка, каскад фототрансдукции

DOI: 10.7868/S3034593625030019

Цитирование для раздела "Список литературы": Фирсов М. Л. Свободная и связанная фракция сgmp в наружном сегменте фоторецепторов позвоночных. Сенсорные системы. 2025. Т. 39. № 3. С. 3–12. doi: 10.7868/S3034593625030019
Цитирование для раздела "References": Firsov M. L. Svobodnaya i svyazannaya fraktsiya sgmp v naruzhnom segmente fotoretseptorov pozvonochnykh [Free and bound fraction of cgmp in the outer segment of vertebrate photoreceptors]. Sensornye sistemy [Sensory systems]. 2025. V. 39(3). P. 3–12 (in Russian). doi: 10.7868/S3034593625030019

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