Известно, что фокальная активность (ФА), регистрируемая в обонятельной луковице (ОЛ), в значительной степени
генерируется в ее локальных нейронных сетях, имеет непосредственное отношение к обработке ольфакторной информации и
подвержена влиянию различных факторов, в том числе анестетиков. С использованием 8-электродных матриц на шести взрослых
самцах серых доминитицированных крыс в хронических экспериментах исследовали эффекты ксилазин-тилетамин-золазепамовой
(КТЗ) анестезии на спектральные характеристики и когерентность ФА, регистрируемой с дорзальной поверхности ОЛ в
частотном диапазоне 1–150 Гц в течение двух часов. Показано, что наиболее существенные изменения в ФА ОЛ крыс в КТЗ-
наркозе наблюдаются в области высоких гамма-частот. Статистически значимое увеличение мощности (в 2–4 раза) и
когерентности (до 50%) этих частот наблюдалось в ФА всех животных уже в течение 10–15 мин от начала наркотизации. При
этом, если в бодрствовании модальные значения этих частот приходились на область 70–80 Гц, то по прошествии указанного
времени – 110–130 Гц. В динамике наркоза наблюдалось постепенное смещение модального значения в распределении их
мощности влево, в область более низких частот (90–110 Гц), при этом их суммарная мощность (но не когерентность)
статистически значимо снижалась лишь на фоне выхода животного из наркоза.
Ключевые слова:
обонятельная луковица, фокальная активность, гамма-активность, когерентность, ксилазин-тилетамин-золазепамовый наркоз
DOI: 10.31857/S0235009223010043
EDN: ATSRWQ
Цитирование для раздела "Список литературы":
Кирой В. Н., Косенко П. О., Шапошников П. Д., Асланян Е. В., Саевский А. И.
Изменение спектральных характеристик и уровня когерентности фокальной активности обонятельной луковицы крысы в динамике ксилазин-тилетаминзолазепамового наркоза.
Сенсорные системы.
2023.
Т. 37.
№ 1.
С. 65–77. doi: 10.31857/S0235009223010043
Цитирование для раздела "References":
Kiroy V. N., VP. O. Kosenko, Shaposhnikov P. D., Saevskiy A. I., Aslanyan E. V.
Izmenenie spektralnykh kharakteristik i urovnya kogerentnosti fokalnoi aktivnosti obonyatelnoi lukovitsy krysy v dinamike ksilazin-tiletaminzolazepamovogo narkoza
[Changes in the spectral characteristics and the coherence of the rat olfactory bulb local field potentials under xylazine-tiletamine-zolazepam anesthesia].
Sensornye sistemy [Sensory systems].
2023.
V. 37(1).
P. 65–77
(in Russian). doi: 10.31857/S0235009223010043
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