Acoustic brainstem evoked potentials as the evaluation tool for the functional state of the central nervous system in children with disseminated encephalomyelitis

© 2016 V. B. Voitenkov, M. Yu. Boboshko, N. V. Skripchenko, A. V. Klimkin, A. V. Surovtseva, E. S. Garbaruk

Scientific Research Institute of Children’s Infections, Saint-Petersburg, Russia, 197022 Professora Popova, 9
First Pavlov State Medical University of St. Petersburg 197022 St. Petersburg, Lev Tolstoy str. 6/8
Saint-Petersburg State Pediatric Medical University 194100 St. Petersburg, Litovskaya str. 2

Received 01 Jun 2015

30 patients (age 12–17 years) with acute disseminated encephalomyelitis (ADEM) were investigated implementing acoustic brainstem evoked potentials (BAEPs). Significant diffuse slowing of the conduction along the brainstem acoustic pathways was discovered. Later its transient nature was proven by the repeated BAEPs investigation 1–2 months after the treatment course. Taking into the account diffuse and transient nature of this slowing, it may not be explained by the local lesion of the brainstem. It may be suggested that this slowing may happen due to brainstem swelling and reticular formation activity inhibition.

Key words: acute disseminated encephalomyelitis, children, acoustic brainstem evoked potentials, reticular formation

Cite: Voitenkov V. B., Boboshko M. Yu., Skripchenko N. V., Klimkin A. V., Surovtseva A. V., Garbaruk E. S.. Akusticheskie stvolovye vyzvannye potentsialy kak instrument otsenki funktsionalnogo sostoyaniya tsentralnoi nervnoi sistemy u detei s disseminirovannym entsefalomielitom [Acoustic brainstem evoked potentials as the evaluation tool for the functional state of the central nervous system in children with disseminated encephalomyelitis]. Sensornye sistemy [Sensory systems]. 2016. V. 30(1). P. 63-68 (in Russian).

References:

  • Altman Ya.A., Tavartkiladze G.A. Handbook on Audiology. Moscow: DMK Press, 2003. 360 p. [in Russian].
  • Gnezditsky V.V., Korepina O.S. Auditory evoked potentials. A neurologist’s view // Contemporary methods of functional diagnosis of hearing / N.Y. Shubina, E.L. Fridman, T.G. Komarova, M.I. Soganov, V.V. Gnezditsky, O.S. Korepina, E.S. Garbaruk, V.E. Gaufman. Iavnovo: PresSto, 2013. P. 41–112 [in Russian].
  • Yefimenko V.N. Problems of diagnostic and prognosis of multiple sclerosis and encephalomyelitis in children // Ukrainskiy nevrologicheskiy jurnal. 2007. N 4 (5). P. 46–52 [in Russian].
  • Komantsev V.N., Skripchenko N.V., Savina M.V., Ivanova G.P. Evoked potentials in neuroinfections in children // Zhurnal infektologii 2013. V. 5 (2). P. 55–62 [in Russian].
  • Lobzin Yu.V., Skripchenko N.V., Ivanova G.P., Komantsev V.N. Disseminated leukoencephalitis and multiple sclerosis: cause and effect // Saratovskiy Medicinskiy Zhurnal. 2013. V. 9 (2). P. 170–178 [in Russian].
  • Nesrullaeva N.A., Shiralieva R.K., Huseynova S.K. The role of multimodal evoked potentials in diagnostics and dynamic analysis in multiple sclerosis // Mir meditsiny i biologii. 2011. V. 7 (4). P. 110–115 [in Russian].
  • Skripchenko N.V., Lobzin Yu.V., Ivanova G.P., Komantsev V.N., Alekseeva L.A., Ivanova M.V., Vil`nic A.A., Gorelik E.Yu., Skripchenko E.Yu. Neuroinfections in children // Detskie Infekcii. 2014. V. 13 (1). P. 8–18 [in Russian].
  • Skripchenko N.V., Ivanova G.P., Komantsev V.N., Savina M.V. Modern features of varicella encephalitis in children // Zhurnal infectologii. 2009. V. 1 (4). P. 36–43 [in Russian].
  • Tavartkiladze G.A. Handbook on Clinical Audiology. Moscow: Meditsina, 2013. 676 p. [in Russian].
  • Shnayder N.A., Krijanovskaya S.V., Panina Yu.S. Violation of auditory afferentation in patients with chronic herpes virus neuroinfection // Rossiyskaya otorinolaringologiya. 2012. N 3. P. 187–193 [in Russian].
  • Arankowsky-Sandoval G., Stone W.S., Gold P.E. Enhance- ment of REM sleep with auditory stimulation in young and old rats // Brain Res. 1992. V. 589 (2). P. 353–357.
  • Bale Jr J.F., Bonkowsky J.L., Filloux F.M., Hedlund G.L., Nielsen D.M., Larsen P.D. Pediatric Neurology // A Color Handbook. CRC Press, 2012. 352 р.
  • Baley J.E., Gonzalez B. Fanaroff and Martin’s Neonatal-Per- inatal Medicine. Philadelphia, Saunders. 2015. 833 p.
  • Benita M., Conde H. Effects of local cooling upon con- duction and synaptic transmission // Brain Res. 1972. V. 36 (1). P. 133–151.
  • Chiappa K.H., Harrison J.L., Brooks E.B., Young R.R. Brainstem auditory evoked responses in 200 patients with multiple sclerosis // Ann. Neurol. 1980. V. 7 (2). P. 135–143.
  • Doufas A.G., Wadhwa A., Shah Y.M., Lin C.M. Block-De- pendent Sedation during Epidural Anaesthesia is Asso- ciated with Delayed Brainstem Conduction // Br. J. An- aesth. 2004. V. 93(2). P. 228–234.
  • Ferguson I.T., Ramsden R.T., Lythgoe M. Brain stem audi- tory evoked potentials and blink reflexes in multiple scle- rosis // J. Laryngol. Otol. 1985. V. 99 (7). P. 677–683.
  • Gonzalez-Lima F., Scheich H. Functional activation in the auditory system of the rat produced by arousing reticu- lar stimulation: a 2-deoxyglucose study // Brain Res. 1984. V. 299 (2). P. 201–214.
  • Hall J.W., Bull J.M., Cronau L.H. Hypo- and hyper- thermia in clinical auditory brain stem response mea- surement: two case reports // Ear Hear. 1988. V. 9 (3). P. 137–143.
  • Hall W.J. New Handbook for Auditory Evoked Responses. Boston: Pearson, 2007. 750 p.
  • Hanefeld F., Bauer H.J., Christen H.J., Kruse B., Bruhn H., Frahm J. Multiple sclerosis in childhood: report of 15 cases // Brain Dev. 1991. V. 13 (6). P. 410–416.
  • Jewett D.L., Williston J.S. Auditory-evoked far fields av- eraged from the scalp of humans // Brain. 1971. V. 94. P. 681–696.
  • Lingenhohl K., Friauf E. Giant neurons in the rat reticu- lar formation: a sensorimotor interface in the elemen- tary acoustic startle circuit? // J. Neurosci. 1994. V. 14. P. 1176–1194.
  • Pokryszko-Dragan A., Bilinska M., Gruszka E., Kusin- ska E., Podemski R. Assessment of visual and audi- tory evoked potentials in multiple sclerosis patients with and without fatigue // Neurol. Sci. 2015. V. 36 (2). P. 235–242.
  • Rosenblum S.M., Ruth R.A., Gal T.J. Brain stem audito- ry evoked potential monitoring during profound hy- pothermia and circulatory arrest // Ann. Otol. Rhinol. Laryngol. 1985. V. 94 (3). P. 281–283.
  • Sand T., Sjaastad O., Romslo I., Sulg I. Brain-stem audi- tory evoked potentials in multiple sclerosis: the relation to VEP, SEP and CSF immunoglobulins // J. Neurol. 1990. V. 237 (6). P. 376–378.
  • Visudtibhan A., Tuntiyathorn L., Vaewpanich J. Acute dis- seminated encephalomyelitis: A 10-year cohort study in Thai children // Europ. J. Pediatric Neurology. 2010. V. 14 (6). P. 513–518.
  • Wang P.J., Tseng C.L., Young C., Liu H.M., Chang Y.C., Shen Y.Z., Lee C.Y. Multiple sclerosis in children: clin- ical, neuroimaging, and neurophysiological correla- tions // Acta Pediatr. Sin. 1995. V. 36 (2). P. 93–100.